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Journal: medRxiv

Article Title: Tumor Patterns and Cancer Risk in Carriers of TP53 exonic Germline Variants that alter mRNA Splicing

doi: 10.1101/2025.09.22.25336167

Figure Lengend Snippet:

Article Snippet: One key methodological difference is that our assay used non-transformed COS1 cells (a fibroblast-like kidney cell line from the African green monkey; ATCC CRL 1650), whereas Fortuno et al. used the human breast cancer cell line SK-BR-3.

Techniques: Functional Assay, Generated, CRISPR, Sequencing